EFL chief executive David Baldwin is to stand down from his role in six months' time.
The former Burnley chief executive only took up the role in June.
But a statement from the league released on Monday confirmed Baldwin will leave in 2021 - a decision totally unrelated to Project Big Picture.
The EFL say the recruitment process for his replacement will begin with "with immediate effect".
Baldwin said: "Having thoroughly reflected on my own personal circumstances at length in recent weeks, I have now determined it is only appropriate to inform the board and the membership of the EFL of my intentions at the earliest opportunity.
"Clearly, accepting this position pre Covid-19 means the situation is now very different to the one I originally envisaged coupled with it being a very different environment inside the EFL, when compared to the one I left in 2015-16.
"Taking those two factors into consideration and balancing the needs of my family, health and well-being, I feel the decision to leave is the right one."
Baldwin added: "Between now and my departure date there is still plenty of work to be undertaken on behalf of EFL clubs and I remain committed to finding solutions to the many challenges we currently face."
EFL chairman Rick Parry added: "Whilst disappointed, I understand the reasons Dave has outlined and respect his wishes. He remains committed to the EFL and will continue to lead the executive until he leaves us in 2021."
England conclude the October international break with a Uefa Nations League clash against Denmark on Wednesday.”
